| Amicable Numbers (searching for pairs of numbers whose divisors sum to each other) | 111,414,587,970 |
| SRBase (searching for primes to resolve Sierpiński and Riesel conjectures) | 38,150,658,371 |
| GPUGrid (simulating molecular dynamics for biomedical research) | 34,690,385,331 |
| Asteroids@Home (computing asteroid orbits to assess planetary impact risk) | 2,157,164,311 |
| SiDock@home (screening drug candidates against disease targets) | 653,509,087 |
| YAFU (factoring large numbers to advance aliquot sequence research) | 340,209,087 |
| Ramanujan Project (discovering new mathematical formulas for fundamental constants like e and pi) | 99,032,650 |
| BOINC Central (multi-project coordination and testing) | 33,952,893 |
| SETI@home (analysing radio telescope data for signs of extraterrestrial intelligence; hibernating since 2020) | 601,632 |
| RNA World (modelling RNA structures to understand the origins of life) | 140,843 |