| SRBase (searching for primes to resolve SierpiĆski and Riesel conjectures) | 38,944,126,951 |
| GPUGrid (simulating molecular dynamics for biomedical research) | 35,684,885,331 |
| Asteroids@Home (computing asteroid orbits to assess planetary impact risk) | 2,171,799,724 |
| SiDock@home (screening drug candidates against disease targets) | 653,460,754 |
| DENIS@home (modelling the dynamics of galaxies using Newtonian N-body simulations; on hiatus) | 152,104,975 |
| SETI@home (analysing radio telescope data for signs of extraterrestrial intelligence; final results published January 2026 after 27 years) | 601,632 |
| RNA World (modelling RNA structures to understand the origins of life) | 140,843 |
| https://rnma.xyz/boinc | 0 |