| SRBase (searching for primes to resolve Sierpiński and Riesel conjectures) | 38,104,249,671 |
| GPUGrid (simulating molecular dynamics for biomedical research) | 34,369,385,331 |
| Asteroids@Home (computing asteroid orbits to assess planetary impact risk) | 2,155,154,496 |
| SiDock@home (screening drug candidates against disease targets) | 653,387,915 |
| YAFU (factoring large numbers to advance aliquot sequence research) | 337,862,351 |
| DENIS@home (modelling the dynamics of galaxies using Newtonian N-body simulations; on hiatus) | 152,104,975 |
| Ramanujan Project (discovering new mathematical formulas for fundamental constants like e and pi) | 99,032,650 |
| SETI@home (analysing radio telescope data for signs of extraterrestrial intelligence; hibernating since 2020) | 601,632 |
| RNA World (modelling RNA structures to understand the origins of life) | 140,843 |