| SRBase (searching for primes to resolve Sierpiński and Riesel conjectures) | 38,539,050,861 |
| GPUGrid (simulating molecular dynamics for biomedical research) | 34,765,385,331 |
| Asteroids@Home (computing asteroid orbits to assess planetary impact risk) | 2,157,959,610 |
| SiDock@home (screening drug candidates against disease targets) | 653,460,754 |
| BOINC Central (multi-project coordination and testing) | 33,955,030 |
| SETI@home (analysing radio telescope data for signs of extraterrestrial intelligence; hibernating since 2020) | 601,632 |
| RNA World (modelling RNA structures to understand the origins of life) | 140,843 |