| SRBase (searching for primes to resolve Sierpiński and Riesel conjectures) | 39,391,117,331 |
| GPUGrid (simulating molecular dynamics for biomedical research) | 36,185,135,331 |
| Asteroids@Home (computing asteroid orbits to assess planetary impact risk) | 2,181,047,379 |
| Rosetta@Home (predicting protein structures to advance drug discovery and disease research) | 1,427,350,942 |
| SiDock@home (screening drug candidates against disease targets) | 653,460,754 |
| BOINC Central (multi-project coordination and testing) | 33,955,704 |
| SETI@home (analysing radio telescope data for signs of extraterrestrial intelligence; final results published January 2026 after 27 years) | 601,632 |
| RNA World (modelling RNA structures to understand the origins of life) | 140,843 |